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Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis

Abstract : Background: Calprotectin (CP) is a protein complex involved in many inflammatory diseases. Obesity is characterized by low-grade inflammation and elevated circulating levels of calprotectin. However, associations between body mass index (BMI) and calprotectin levels have not been explored in otherwise healthy children. Methods: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed and Cochrane Library database up to July 2019. Healthy children's blood calprotectin values were extracted, and potential correlations were explored. Results: A total of six studies that included data on 593 healthy children were identified. Median calprotectin value was 900.0 (482.0; 1700) ng.mL(-1). Multivariable analysis showed no significant associations with age, sample type (serum vs. plasma), or sex. In contrast, a significant effect of BMI z-score (p < 0.001) emerged. Indeed, a positive correlation between BMI z-score and CP, was detected in girls (R: 0.48; p < 0.001) and boys (R: 0.39; p < 0.001). Conclusion: Calprotectin blood levels correlate with the degree of adiposity in healthy children, but are not affected by age, sex, or sample type (serum or plasma).
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https://hal.archives-ouvertes.fr/hal-02978698
Contributor : Hal Lapsco <>
Submitted on : Wednesday, March 31, 2021 - 1:48:42 PM
Last modification on : Thursday, April 1, 2021 - 3:08:22 AM

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Anais Grand, Emmanuelle Rochette, Frédéric Dutheil, David Gozal, Valeria Calcaterra, et al.. Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis. Journal of Clinical Medicine, MDPI, 2020, 9 (3), pp.857. ⟨10.3390/jcm9030857⟩. ⟨hal-02978698⟩

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