The relationship between monocarboxylate transporters 1 and 4 expression in skeletal muscle and endurance performance in athletes

Claire Thomas; David J. Bentley; Belle Roels; Robert Ives; Jacques Mercier; Grégoire Millet; David Cameron-Smith

doi:10.1007%2Fs00421-009-1034-5

The relationship between monocarboxylate transporters 1 and 4 expression in skeletal muscle and endurance performance in athletes

Claire Thomas ^{1, 2} David J. Bentley ³ Belle Roels ^{4, 2} Robert Ives ³ Jacques Mercier ^{5, 2} Grégoire Millet ⁶ David Cameron-Smith ⁷

1 UEVE - Université d'Évry-Val-d'Essonne

2 UM1 Médecine - Montpellier 1 - UFR de Médecine

3 UNSW - University of New South Wales [Sydney]

4 UPRES EA 3759 ‘‘Multidisciplinary Approach of Doping’’,

UM - Université de Montpellier

5 Muscle et Pathologies - INSERM ERI 25

6 Institut des sciences du sport et de l’éducation physique

7 School of Exercise and Nutrition Sciences

Abstract : The purpose of this study was to examine the relationship between skeletal muscle monocarboxylate transporters 1 and 4 (MCT1 and MCT4) expression, skeletal muscle oxidative capacity and endurance performance in trained cyclists. Ten well-trained cyclists (mean ± SD; age 24.4 ± 2.8 years, body mass 73.2 ± 8.3 kg, VO2max 58 ± 7 ml kg−1 min−1) completed three endurance performance tasks [incremental exercise test to exhaustion, 2 and 10 min time trial (TT)]. In addition, a muscle biopsy sample from the vastus lateralis muscle was analysed for MCT1 and MCT4 expression levels together with the activity of citrate synthase (CS) and 3-hydroxyacyl-CoA dehydrogenase (HAD). There was a tendency for VO2max and peak power output obtained in the incremental exercise test to be correlated with MCT1 (r = −0.71 to −0.74; P < 0.06), but not MCT4. The average power output (Paverage) in the 2 min TT was significantly correlated with MCT4 (r = −0.74; P < 0.05) and HAD (r = −0.92; P < 0.01). The Paverage in the 10 min TT was only correlated with CS activity (r = 0.68; P < 0.05). These results indicate the relationship between MCT1 and MCT4 as well as cycle TT performance may be influenced by the length and intensity of the task.

Keywords : Correlation Cycling Power Regulation Aerobic

Type de document :

Article dans une revue

European Journal of Applied Physiology, Springer Verlag, 2009, 106 (3), pp.465-471. 〈10.1007%2Fs00421-009-1034-5〉

Domaine :

Sciences de l'Homme et Société / Sport

Sciences de l'Homme et Société / Sport / Physiologie du sport

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