The relationship between monocarboxylate transporters 1 and 4 expression in skeletal muscle and endurance performance in athletes

Claire Thomas 1, 2 David J. Bentley 3 Belle Roels 4, 2 Robert Ives 3 Jacques Mercier 5, 2 Grégoire Millet 6 David Cameron-Smith 7
1 UEVE - Université d'Évry-Val-d'Essonne
2 UM1 Médecine - Montpellier 1 - UFR de Médecine
3 UNSW - University of New South Wales [Sydney]
4 EuroMov - Euromov
5 Muscles et pathologies
6 Institut des sciences du sport et de l’éducation physique
7 School of Exercise and Nutrition Sciences
Abstract : The purpose of this study was to examine the relationship between skeletal muscle monocarboxylate transporters 1 and 4 (MCT1 and MCT4) expression, skeletal muscle oxidative capacity and endurance performance in trained cyclists. Ten well-trained cyclists (mean ± SD; age 24.4 ± 2.8 years, body mass 73.2 ± 8.3 kg, VO2max 58 ± 7 ml kg−1 min−1) completed three endurance performance tasks [incremental exercise test to exhaustion, 2 and 10 min time trial (TT)]. In addition, a muscle biopsy sample from the vastus lateralis muscle was analysed for MCT1 and MCT4 expression levels together with the activity of citrate synthase (CS) and 3-hydroxyacyl-CoA dehydrogenase (HAD). There was a tendency for VO2max and peak power output obtained in the incremental exercise test to be correlated with MCT1 (r = −0.71 to −0.74; P < 0.06), but not MCT4. The average power output (Paverage) in the 2 min TT was significantly correlated with MCT4 (r = −0.74; P < 0.05) and HAD (r = −0.92; P < 0.01). The Paverage in the 10 min TT was only correlated with CS activity (r = 0.68; P < 0.05). These results indicate the relationship between MCT1 and MCT4 as well as cycle TT performance may be influenced by the length and intensity of the task.
Keywords : Correlation Cycling Power Regulation Aerobic
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Claire Thomas, David J. Bentley, Belle Roels, Robert Ives, Jacques Mercier, et al.. The relationship between monocarboxylate transporters 1 and 4 expression in skeletal muscle and endurance performance in athletes. European Journal of Applied Physiology, Springer Verlag, 2009, 106 (3), pp.465-471. ⟨10.1007%2Fs00421-009-1034-5⟩. ⟨hal-01585630⟩

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