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Article dans une revue
Effect of intermittent hypoxic training on HIF gene expression in human skeletal muscle and leukocytes
Abstract : Intermittent hypoxic exposure with exercise
training is based on the assumption that brief exposure to
hypoxia is suYcient to induce beneWcial muscular adaptations
mediated via hypoxia-inducible transcription factors
(HIF). We previously demonstrated (Mounier et al. Med
Sci Sports Exerc 38:1410–1417, 2006) that leukocytes
respond to hypoxia with a marked inter-individual variability
in HIF-1 mRNA. This study compared the eVects of
3 weeks of intermittent hypoxic training on hif gene expression
in both skeletal muscle and leukocytes. Male endurance
athletes (n = 19) were divided into an Intermittent Hypoxic
Exposure group (IHE) and a Normoxic Training group
(NT) with each group following a similar 3-week exercise
training program. After training, the amount of HIF-1
mRNA in muscle decreased only in IHE group (¡24.7%,
P < 0.05) whereas it remained unchanged in leukocytes in
both groups. The levels of vEGF121 and vEGF165 mRNA in
skeletal muscle increased signiWcantly after training only in
the NT group (+82.5%, P < 0.05 for vEGF121; +41.2%,
P < 0.05 for vEGF165). In leukocytes, only the IHE group
showed a signiWcant change in vEGF165 (¡28.2%,
P < 0.05). The signiWcant decrease in HIF-1 mRNA in
skeletal muscle after hypoxic training suggests that transcriptional
and post-transcriptional regulations of the hif-1
gene are diVerent in muscle and leukocytes.
https://hal-insep.archives-ouvertes.fr/hal-01587180
Contributeur : Documentation Insep <>
Soumis le : mercredi 13 septembre 2017 - 17:41:48
Dernière modification le : lundi 15 mars 2021 - 14:26:55
Contributeur : Documentation Insep <>
Soumis le : mercredi 13 septembre 2017 - 17:41:48
Dernière modification le : lundi 15 mars 2021 - 14:26:55
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