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Acute induction of uncoupling protein 1 by citrulline in cultured explants of white adipose tissue from lean and high-fat-diet-fed rats
Abstract : A diet enriched with citrulline (CIT) reduces white adipose tissue (WAT) mass. We recently showed that CIT
stimulated β-oxidation in rat WAT explants from young (2–4 months) but not old (25 months) rats. Here we show that
both in old rats and high-fat-diet-fed young rats, uncoupling protein one (UCP1) mRNA and protein expressions were
weaker than those in young control rats. Selectively in WAT from young rats, a 24h CIT treatment up-regulated
expressions of UCP1, peroxisome proliferator-activated receptor-x (PPARx/, PPARy-coactivator-1-x and mitochondrialtranscription-
factor-A whereas it down-regulated PPARy gene expression, whatever the diet. These results suggest
that CIT induces a new metabolic status in WAT, with increased β-oxidation and uncoupling of respiratory chain,
resulting in energy expenditure that favors fat mass reduction.
https://hal-insep.archives-ouvertes.fr/hal-01772974
Contributeur : Documentation Insep <>
Soumis le : vendredi 20 avril 2018 - 16:33:21
Dernière modification le : vendredi 26 mars 2021 - 10:42:02
Contributeur : Documentation Insep <>
Soumis le : vendredi 20 avril 2018 - 16:33:21
Dernière modification le : vendredi 26 mars 2021 - 10:42:02
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