An integrative modeling approach to the age-performance relationship in mammals at the cellular scale

Abstract : Physical and cognitive performances change across lifespan. Studying cohorts of individuals in specific age ranges and athletic abilities remains essential in assessing the underlying physiological mechanisms that result in such a drop in performance. This decline is now viewed as a unique phenotypic biomarker and a hallmark of the aging process. The rates of decline are well documented for sets of traits such as running or swimming but only a limited number of studies have examined the developmental and senescent phases together. Moreover, the few attempts to do so are merely descriptive and do not include any meaningful biological features. Here we propose an averaged and deterministic model, based on cell population dynamics, replicative senescence and functionality loss. It describes the age-related change of performance in 17 time-series phenotypic traits, including human physical and cognitive skills, mouse lemur strength, greyhound and thoroughbred speed, and mouse activity. We demonstrate that the estimated age of peak performance occurs in the early part of life (20.5% ± 6.6% of the estimated lifespan) thus emphasizing the asymmetrical nature of the relationship. This model is an initial attempt to relate performance dynamics to cellular dynamics and will lead to more sophisticated models in the future.
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Soumis le : mercredi 30 janvier 2019 - 11:59:10
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Geoffroy Berthelot, Avner Bar-Hen, Adrien Marck, Vincent Foulonneau, Stéphane Douady, et al.. An integrative modeling approach to the age-performance relationship in mammals at the cellular scale. Scientific Reports, Nature Publishing Group, 2019, ⟨10.1038/s41598-018-36707-3⟩. ⟨hal-01999904⟩

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